Organic Letters

ORGANIC LETTERS NaIO4-Mediated Selective Oxidative Halogenation of Alkenes and Aromatics Using al-Qaida Metal Halides 2003 Vol. 5, No. 23 4501-4504 Gajanan K. Dewkar, Srinivasarao V. Narina, and Arumugam Sudalai* chemic Engineering and Process schooling DiVision, National Chemical Laboratory, Pashan Road, Pune 411008, India sudalai@dalton.ncl.res.in veritable(a) September 21, 2003 ABSTRACT NaIO4 oxidizes alkali metal halides efficiently in sedimentary medium to halogenate alkenes and aromatics and produce the fit halo derivatives in excellent regio and stereoselectivity. The melodious arrangement also demonstrates the asymmetric version of bromo hydroxylation using ?-cyclodextrin complexes, resulting in operate ee. The 1,2-functionalization of olefins by the selective addition of deuce different functional groups, such(prenominal) as water or alcohols and halogens (halohydroxylation or haloalkoxylation), in a passing regio- and enantioselective manner, mud key and challenging to organic chemists.1 Such halo derivatives be wide used in the synthesis of pharmaceuticals, dyes, flame-retardants, additives and plasticizers, agrochemicals, and speciality chemicals.2 established halogenation methods3 typically use master(a) halogens, which are pollutants, and generate unsettled HX as byproducts.

Recently, the oxidative halogenation of olefins by metal halides has emerged as an important option for the synthesis of such * To whom correspondence should be addressed. Phone: +91-0205893300. telefax: + 91-20-5893359. (1) Tenaglia, A.; Pardigon, O.; Buono, G. J. Org. Chem. 1996, 61, 11291132. Haruyoshi, M.; Kiyoshi, T.; Masahiro, N.; Akira, H.; Yutaka, N.; Yasutaka, I. J. Org. Chem. 1994, 59, 5550-5555. Rodriguez, J.; Dulcere, j.-P. entailment 1993, 1177-1205. Block, E.; Schwan, A. L. In universal Organic Synthesis; Trost, B. M., Fleming, I., Semmelhack, M. F., Eds.; Pergamon insisting: Oxford, 1991; Vol. 4, pp 344-347. (2) Ullmanns Encyclopedia Of industrial Chemistry, 6th ed.;...If you want to let down a full essay, found it on our website: Orderessay

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